Role of P-glycoprotein in the pharmacotherapy of pregnant women

Role of P-glycoprotein in the pharmacotherapy of pregnant women

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This review addresses the function of the protein-transporter glycoprotein-P (Pgp, ABCB1 protein) and the expression enchanted wonderstruck perfume of its encoding gene MDR1/mdr1 throughout the gestational period in humans and animals.We discuss the relationship between the transporter function and the hormone fluctuations during pregnancy.We cite studies on the association between the MDR1/mdr1 gene copyright tiki mug polymorphisms and the hemato-placental barrier permeability for Pgp substrates, as well as fetal malformations.

Under a separate section, drugs commonly used in pregnant women are characterized in terms of their roles as substrates, inducers or inhibitors of the Pgp transporter.